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Table 1 LRP1 expression in MS: 6 clinical and pathologically confirmed multiple sclerosis autopsy samples were analyzed

From: LRP1 expression in microglia is protective during CNS autoimmunity

Lesion stage from MS autopsy

LRP1 expression in the Lesion

Myeloid Cells

Neurons

Astrocytes

Early Active

100 % (2/2)

NAa (0/2)

100 % (2/2)

Late Active

0 % (0/1)

NAa (0/1)

100 % (1/1)

Periplaque White Matter

0 % (0/5)

NAa (0/5)

100 % (5/5)

Non-Affected White Matter

0 % (0/5)

NAa (0/5)

100 % (5/5)

Chronic Demyelination

0 % (0/4)

100 % (4/4)

100 % (4/4)

Non-Affected Gray Matter

0 % (0/5)

100 % (5/5)

100 % (5/5)

  1. Formalin-fixed paraffin-embedded 5 μm thick sections were stained for H&E, Luxol fast blue and periodic acid Schiff (LFB/PAS), and Bielschowsky’s silver stain for routine pathology analysis. For cellular analysis, slides were stained for LRP1, myeloid marker CD68, and reactive astrocyte marker GFAP. Neurons were not detected in white matter
  2. a NA not applicable
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Acta Neuropathologica Communications

ISSN: 2051-5960

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