Fig. 3

Loss of NRG1-positive puncta in the spinal motor neurons of sporadic ALS and control patients. (a, b) Representative images of lumbar spinal cord of the control (a) and sporadic ALS patients (b) stained with NRG1 (green), ChAT (red), and DAPI (blue). Magnification: 20x. (c) Quantification of mean NRG1-positive puncta per motor neuron from indicated regions of spinal cords from control and ALS patients (n = 3, each). **: p <0.01 by one-way ANOVA