Fig. 3

Gender influences protein oxidative modification and p21 expresssion lumbar spinal cords in G93A mice. Graph shows values for protein oxidative markers AASA (a) and GSA (b), protein glycoxidative modifications CEL (c) and CML (d), and lipid peroxidation derived damage MDAL (e). Values shown are means ± SEM expressed as μmol of analyte per mol lysine. f Representative immunofluorescence image of lumbar spinal cord slices from G93A mice showing increased p21 levels in females compared with males, as quantified in g. ^abc indicate, significant effects (p < 0.01) of age, gender and their interaction, respectively, after 2 way ANOVA. * shows significant differences for Bonferroni post-hoc (or Student’s t test for g) analyses (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001) between genders at a given age. Bars in e are 30 μm long