The NOTCH3 score: a pre-clinical CADASIL biomarker in a novel human genomic NOTCH3 transgenic mouse model with early progressive vascular NOTCH3 accumulation

Table 1 The NOTCH3 RNA expression level correlates with the age at onset of cerebrovascular NOTCH3 protein accumulation

Mouse strain	NOTCH3 expression level^a	Age at onset NOTCH3 accumulation^b
tgN3^MUT 350	350 %	6 weeks
tgN3^MUT 200	200 %	3 months
tgN3^MUT 150	150 %	5 months
tgN3^MUT 100	100 %	12 months

^a mRNA NOTCH3 expression levels relative to endogenous mouse Notch3 expression levels ^b first sign of positive, granular NOTCH3 staining in brain vessels, as determined by an experienced neuropathologist (S.v.D)

ISSN: 2051-5960