Table 1 Pediatric tumor cohorts

PGNT

Papillary glioneuronal

I

Frontal lobe

M

14

nd

PA1

Pilocytic astrocytoma

I

Posterior fossa

F

16

KIAA1549-BRAF exon 16-exon 9

PA2

Pilocytic astrocytoma

I

Posterior fossa

M

12

KIAA1549-BRAF exon 16-exon 9

PA3

Pilocytic astrocytoma

I

Posterior fossa

M

14

KIAA1549-BRAF exon 16-exon 9

PA5

Pilocytic astrocytoma

I

Posterior fossa

F

3

KIAA1549-BRAF exon 16-exon 9

PA6

Pilocytic astrocytoma

I

Cerebellum

F

8

KIAA1549-BRAF exon 15-exon 9

PA7

Pilocytic astrocytoma

I

Cerebellum

M

1

KIAA1549-BRAF exon 16-exon 11

PA8

Pilocytic astrocytoma

I

Cerebellum

M

1

KIAA1549-BRAF exon 16-exon 9

PA9

Pilocytic astrocytoma

I

Cerebellum

F

2

KIAA1549-BRAF exon 16-exon 11

PA10

Pilocytic astrocytoma

I

Cerebellum

M

2

KIAA1549-BRAF exon 16-exon 9

PA11

Pilocytic astrocytoma

I

Cerebellum

M

6

KIAA1549-BRAF exon 16-exon 9

PA12

Pilocytic astrocytoma

I

Cerebellum

F

11

KIAA1549-BRAF exon 15-exon 9

PA13

Pilocytic astrocytoma

I

Posterior fossa

M

4

KIAA1549-BRAF exon 16-exon 9

PA14

Pilocytic astrocytoma

I

Posterior fossa

F

6

KIAA1549-BRAF exon 16-exon 9

PA15

Pilocytic astrocytoma

I

Posterior fossa

M

9

KIAA1549-BRAF exon 16-exon 9

DA1

Diffuse astrocytoma

II

Temporal lobe

F

12

No BRAFV600E

DA2

Diffuse astrocytoma

II

Unknown

F

14

No BRAFV600E

DA3

Diffuse astrocytoma

II

Occipital lobe

M

4

nd

DA4 *

Diffuse astrocytoma

II

Unknown

M

17

BRAFV600E present

AA1

Anaplastic astrocytoma

III

Conus medullaris

M

15

nd

AA2

Anaplastic astrocytoma

III

Temporal lobe

F

3

No BRAFV600E

AA3 *

Anaplastic astrocytoma

III

Unknown

F

11

No BRAFV600E

GBM1

Glioblastoma

IV

Frontal lobe

F

15

No BRAFV600E

GBM2

Glioblastoma

IV

Temporoparietal

M

10

No BRAFV600E

GBM3

Glioblastoma

IV

Brainstem

F

4

nd

GBM4

Glioblastoma

IV

Left frontal lobe

F

10

No BRAFV600E

GBM5

Glioblastoma

IV

Spinal cord

F

7

nd

E1

Ependymoma

III

Posterior fossa

M

4

E2

Ependymoma

III

Parietal lobe

F

6

E3

Ependymoma

II

Posterior fossa

F

2

E4

Ependymoma

III

Posterior fossa

F

2

E5

Ependymoma

II

Temporal lobe

M

12

E6

Ependymoma

III

Posterior fossa

M

6

E7

Ependymoma

III

Posterior fossa

M

2

E8

Ependymoma

II

Supratentorial (frontal)

M

14

E9

Ependymoma

II

Posterior fossa

M

3

E10

Ependymoma

II

Posterior fossa

M

4

E11

Ependymoma

III

Posterior fossa

F

nd

E12

Ependymoma

III

Fourth ventricle

M

1

E13

Ependymoma

II

Spinal seed

F

6

E14

Ependymoma

III

Posterior fossa

F

6

M1

Medulloblastoma

IV

Posterior fossa

M

4

M2

Medulloblastoma

IV

Posterior fossa

M

1

M3

Medulloblastoma

IV

Posterior fossa

F

6 months

M4

Medulloblastoma

IV

Posterior fossa

M

7

M5

Medulloblastoma

IV

Posterior fossa

M

3

M6

Medulloblastoma

IV

Posterior fossa

M

9

M7

Medulloblastoma

IV

Posterior fossa

M

7

M8

Medulloblastoma

IV

Posterior fossa

M

9

M9

Medulloblastoma

IV

Posterior fossa

M

4

M10 *

Medulloblastoma

IV

Posterior fossa

F

5

R1

Atypical Rhabdoid

IV

Brainstem

M

1

R2

Atypical Rhabdoid

IV

Posterior fossa

F

7 months

R3

Atypical Rhabdoid

IV

Supratentorial

F

2

R4

Atypical Rhabdoid

IV

Posterior fossa

M

9 months

R5

Atypical Rhabdoid

IV

Posterior fossa

F

2 months

P1

Choroid Plexus Papilloma

I

Intraventricular (frontal lateral ventricle)

M

10 months

P2

Choroid Plexus Papilloma

I

Posterior fossa

M

1

P3

Choroid Plexus Papilloma

I

Left lateral ventricle

M

3

P4

Choroid Plexus Papilloma

I

Unknown

F

nd

AC1

Adult control cerebellum

Cerebellum

M

22

AC2

Adult control frontal lobe

Frontal lobe

M

41

AC3

Adult control cerebellum

Cerebellum

M

21

AC4

Adult control cerebellum

Cerebellum

M

26

AC5

Adult control frontal lobe

Frontal lobe

M

82

AC6

Adult control frontal lobe

Frontal lobe

M

25

AC7

Adult control frontal lobe

Frontal lobe

M

27

PA16

Pilocytic astrocytoma

I

Posterior fossa

M

9

nd

PA17

Pilocytic astrocytoma

I

Posterior fossa

M

12

nd

PA18

Pilocytic astrocytoma

I

Suprasellar

M

3

KIAA1549-BRAF exon 15-exon 9

PA19

Pilocytic astrocytoma

I

3^rd ventricle

M

16

nd

PA20

Pilocytic astrocytoma

I

Brain stem

F

3

KIAA1549-BRAF exon 15-exon 9

PA21

Pilocytic astrocytoma

I

Posterior fossa

F

4

KIAA1549-BRAF exon 16-exon 9

PA22

Pilocytic astrocytoma

I

Posterior fossa

M

16

KIAA1549-BRAF exon 16-exon 9

PA23

Pilocytic astrocytoma

I

Posterior fossa

F

2

KIAA1549-BRAF exon 16-exon 11

PA24

Pilocytic astrocytoma

I

Posterior fossa

F

12

KIAA1549-BRAF exon 16-exon 9

GBM6

Glioblastoma

IV

Midbrain/Thalamus

F

14

-

GBM7

Glioblastoma

IV

Occipital lobe

M

4 months

-

GBM8

Glioblastoma

IV

Thalamic/intraventriclar

F

10

-

GBM9

Glioblastoma

II

Thalamic

M

15

-