Fig. 2From: PI3 kinase mutations and mutational load as poor prognostic markers in diffuse glioma patientsSurvival in prognostic molecular subtypes of diffuse glioma stratified by tumor grade. Different subtypes are indicated above each graph. As can be seen, within defined molecular subtypes, tumor grade remains a prognostic factor. Number of samples (grade II, III and IV) for each graph: 10, 42 and 248 (IDH-wt); 73, 65 and 13 (IDH-mut, ATRX/TP53 mut); 42, 32 and 0 (IDH-mut, 1p19q codeleted). 17 samples were IDH-mut but had neither ATRX/TP53 mutations nor 1p19q codeletion. P values indicated are calculated using the Log-rank test; other test for significance show for IDH-wt tumors a P = 0.0092 and for IDH-mut, ATRX/TP53 mut tumors a P = 0.0034 (both logrank test for trend); for IDH-mut, 1p19q codeleted) a P = 0.28 (Gehan Breslow Wilcoxon test). Log rank P values for grade II v. III are 0.43 and 0.063 for IDH-wt and IDH-mut, ATRX/TP53 mut tumors respectivelyBack to article page