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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells

Fig. 7

C99 A2T cells were treated with CHAPSO and fractionated using sucrose gradient centrifugation (a). The presenilin 1 carboxyl terminal fragment (PS1CTF) was enriched in raft fractions (#4 and #5). C99 was also distributed in these fractions, in part. However, C99 A2T distribution was significantly shifted into denser fractions (#5 and #6) compared with C99 WT (#4, #5, and #6) (b). Data represent means ± SD of three independent experiments. NS, not significant. *P < 0.05 (unpaired t-test)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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