Transcriptional profiling of differentially vulnerable motor neurons at pre-symptomatic stage in the Smn 2b/- mouse model of spinal muscular atrophy

Table 3 Statistically altered functional clusters of transcripts that are differentially expressed in SMAv compared to WTv and SMAr

Down in SMAv		Up in SMAv
Cluster	Enrichment	Cluster	Enrichment
Metal Ion Binding	3.07	Mitochondrial inner membrane	1.38
Positive regulation of transcription	2.52
Membrane	1.73
Chromatin/methylation	1.47
Positive regulation of DNA repair	1.38
Nucleotide Binding	1.35

Listed clusters are generated from functional annotations which were significantly enriched during functional annotation clustering. Significant enrichment was considered to be those clusters with an enrichment score of >1.3

ISSN: 2051-5960