Fig. 7
From: Impact of amyloid β aggregate maturation on antibody treatment in APP23 mice
Serum Aβ immunoprecipitated by protein-G bound antibodies in APP23 mice: Effects of β1 antibody treatment. Semiquantitative assessments of western blot analysis of blood serum for Aβ and immunoprecipitation of intrinsic serum antibodies by incubation with protein G-coated magnetic beads and with subsequent western blotting for Aβ. Aβ was only seen in 5-month-old β1-treated APP23 mice after antibody-immunoprecipitation and detection with anti-Aβ1–17 (6E10) (* p < 0.05). AβN3pE and pAβ were not found in these precipitates. PBS-treated and 5-month-old mice did not exhibit detectable amounts of Aβ. Graphs represent mean values (white symbols 5-month-old mice; black symbols 11-month-old mice) and standard errors (whiskers). (Full blots Additional file 11: Figure S8; Statistical analysis in Additional file 3: Table S3)