Fig. 3From: High copy wildtype human 1N4R tau expression promotes early pathological tauopathy accompanied by cognitive deficits without progressive neurofibrillary degenerationTau4RTg2652 mice accumulate abundant MC1 immunoreactivity across multiple brain regions. At three months of age (a-e) MC1 immunoreactivity is robust in deep layers of the cortex and throughout the hippocampus and is more moderate in the hindbrain. By one year (f-j), MC1 immunostaining in the forebrain has spread to all cortical layers and throughout the striatum. Scale bars = 500umBack to article page