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Table 1 Demographic features of cases with AD, normal aging, and CBD

From: Ultrastructural differences in pretangles between Alzheimer disease and corticobasal degeneration revealed by comparative light and electron microscopy

 

Pathological diagnosis

Age of death (y)/sex

Brain weight (g)

Duration (y)

Braak NFT stage

Clinical symptoms

Type of tau-positive inclusions investigated

Case 1

Normal aging

73/F

1,260

na

I

No history of dementia or motor symptoms

Pretangles, NFTs

Case 2

AD

58/F

850

14

VI

Severe dementia, disorientation

Pretangles, NFTs

Case 3

CBD

60/M

1,145

7

I

Supranuclear gaze palsy, frequent fall, parkinsonism, frontal signs

Pretangles, Pick-like inclusions*

Case 4

CBD

70/F

770

11

III

Frontotemporal dementia, parkinsonism

Pretangles, Pick-like inclusions, ballooned neurons

  1. *Pick-like inclusions denoting densely packed round inclusions usually observed in the small-sized cortical neurons in corticobasal degeneration; AD, Alzheimer disease; CBD, corticobasal degeneration; NFT, neurofibrillary tangle.