Figure 6

Hypothetical model of synaptic, post-synaptic and axonal pathological events induced by Aβ in a cortico-hippocampal neuronal network. β-amyloid application to the somato-dendritic compartment triggers a so-called “dying-back” leading to a rapid cortical presynaptic loss concomitant with a postsynaptic hippocampal Tau-phosphorylation which could be prevented by the NMDA-receptor antagonist, MK-801, before any sign of axonal and somato-dendritic cortical alteration.