Figure 3

Expression of chromatin remodeling genes identified as being over-represented in i17q in prior studies. Boxplots indicate expression levels as identified in expression microarrays for 103 MBs for each molecular variant. The data are normalized based on the number of probes per feature, allowing for direct comparisons of expression across different genes. Black lines indicate the mean values while the box includes data within one standard deviation. P values are calculated as variance from the grand mean of all MB, or ANOVA (one way). A. Expression of MLL3 in the four molecular MB variants. MLL3 is significantly differentially expressed across the molecular variants with groups 3 and 4 having higher levels, unlike the other genes identified. B, C, D. Expression levels of KDM6A, ZMYM3, and GPS2 across the four MB variants. There is no significant difference in expression of these genes from the grand mean that correlate with i17q-associated variants.