Table 3 Neuropathology overview of foetuses interrupted for polymicrogyria like cortical dysplasia

LIS_TUB_012_ fœtus22

TUBA1A

F

c.214 C > T

p.P72S

37,8

Unlayered Generalized and Asym PMG (fronto-central predominant)

-

Nodular Heterotopia

N/A

N

N/A

N/A

HypoCC

Severe

Severe pons hypoplasia

N/A

5th p

Absent

This series

Vermian Hypoplasia

Mild hypoplasia of the CST

LIS_TUB_043_foetus11

TUBA1A

M

c.641G > A

p.R214H

23

Unlayered Central and Asym PMG

Focal

+

unilat

N/A

-

N

c.ACC

Mild Vermian Hypoplasia

Mild dysplasic olivary nuclei

N/A

10th p

Absent

This series

Unilateral hypoplasia of the CST

LIS_TUB_048_foetus16

TUBB2B

M

c.742G > A

p.A248T

28,5

Unlayered Central and Asym-multifocal PMG

-

Dispersed heterotopic neurons

+

N/A

N/A

N

N

Mild Vermian Hypoplasia

Normal

5th p

Absent

This series

LIS_TUB_053_foetus21

TUBA1A

F

c.473C > T

p.S158L

24,5

Unlayered Generalized and AsymPMG

-

Radial columnar heterotopic neurons

+

Dysmorphic

+

Hypoplasic

c.ACC

Severe Hypoplasia and Dysplasia

Hypoplasia Olivar heterotopia

-

5th p

Absent

This series

Disorganized CST

LIS_TUB_054_foetus15

TUBB2B

M

c.518C > T

p.P173L

25

Unlayered Generalized and AsymPMG (central regions)

-

-

N/A

N/A

N/A

Dysmorphic

c.ACC

Moderate hypoplasia

Severe pons hypoplasia

N/A

<3rd p

Absent

This series

Disorganized CST

LIS_TUB_056_foetus12

TUBB2B

M

c.514 T > C

p.S172P

27

Unlayered Generalized and Asym PMG (fronto-central predominant)

Focal

Radial columnar heterotopic neurons

-

N

-

N

c.ACC

Mild Vermian Dysplasia

Normal

N/A

<3rd p

Absent

[23]

Disorganized CST