Figure 2

Hallmarks of microlissencephaly in a 25 WG foetus (LIS_TUB_005_foetus01) with TUBA1A mutation Macroscopical data with abnormally short agyric hemispheres, severe hypoplastic brain stem and cerebellum (white arrow) (a), Smooth brain surface with no sylvian fissure (b), Smooth brain surface with agenesis of the corpus callosum without Probst bundles (arrow), and voluminous germinal zones (c), No individualized cortical plate but a thin layer made up of immature cells is present at the surface of the hemispheres (d), numerous heterotopias either radial (thin arrow) or columnar (thick arrow) in the white matter (e), with focal neuroglial cell overmigration within the meningeal spaces (f), (Scale bars: a, b: 1 mm, c: 50 μm, d, f: 20 μm, e: 100 μm).