Figure 2
From: CNS-targeted glucocorticoid reduces pathology in mouse model of amyotrophic lateral sclerosis
Changes in T 2 MR signal intensity in cranial motor nuclei following steroid treatment. An increase in signal is present in the trigeminal (V), facial (VII) and hypoglossal (XII) nuclei in SOD1 G93A saline mice (D-F) compared to WT animals (A-C). A comparable signal increase in seen for SOD1 G93A mice treated with free MP (G-I), but in comparison to saline and free MP treated SOD1 G93A mice, those treated with 2B3-201 (J-L) show a markedly reduced signal intensity in these three motor nuclei. These data are presented graphically for the trigeminal, facial and hypoglossal nuclei in M-O respectively. * p < 0.05; ** p<0.01; *** p<0.001.