Figure 1
From: Arsenic trioxide inhibits Hedgehog, Notch and stem cell properties in glioblastoma neurospheres
Arsenic trioxide inhibits glioblastoma neurosphere growth and proliferation. A) MTS assays showing growth inhibition following ATO treatment in the 040821, HSR-GBM1 and 040622 glioblastoma neurosphere lines, with a bar graph highlighting the significance compared to vehicle. B) Representative BRDU staining images showing anti-BRDU staining (red) and DAPI counterstaining (blue) in vehicle and 5 μM ATO-treated 040622 neurosphere cells are shown in the top left panel. The percentage of BRDU positive cells in 040622, 040821 and HSR-GBM1 neurospheres was significantly decreased in all three lines after treatment with either 2.5 μM or 5 μM ATO.