Figure 6

Immunogold labeling TEM showing neuroblastoma cells treated with 10 μM oligomeric Aβ. a) The images reveal dityrosine (10 nm) and Aβ42 (5 nm) labeling within the lysosomes of treated cells. b) low level dityrosine labeling was observed within lysosomes in vehicle treated, control cells, but no Aβ labeling was observed. c) Cells were observed containing fibrillar Aβ labeled for both Aβ (5 nm) and dityrosine (10 nm). White arrows are used to highlight the fibrillar material. Inserts show magnified images for further clarity.