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Table 2 Demographics and clinical parameters of the patients studied for plasma antibodies against oxidized lipid epitopes

From: Lipid accumulation, lipid oxidation, and low plasma levels of acquired antibodies against oxidized lipids associate with degeneration and rupture of the intracranial aneurysm wall

Variables

Bleeding status

P-value

 

No SAH

Prior SAH

 

(n = 41)

(n = 84)

A. Patients

   

Age (years)

54y. (28–70)

55.5y. (11–84)

0.298

Gender (females)

71% (30/42)

71% (60/84)

1.00

Patients with multiple sIAs (≥2)

36% (15/42)

46% (39/84)

0.340

Patients with more than one known aneurysmal SAH

-

4% (3/84)

NA

Severity of the SAH (Hunt&Hess-grading)

  

NA

   0 (no bleeding)

42

-

 

   1 (asymptomatic or mild headache / nuchal rigidity)

-

7% (6/84)

 

   2 (moderate headache / nuchal rigidity)

-

31% (26/84)

 

   3 (drowsiness/confusion, mild neurological deficit)

-

27% (23/84)

 

   4 (stupor, moderate-severe hemiparesis)

-

18% (15/84)

 

   5 (coma or decerebrate posturing)

-

8% (7/84)

 

   Hunt & Hess for the prior bleeding not known

 

7% (6/84)

 

Known familial background

29% (12/42)

7% (6/84)

<0.001*

Smoking

  

<0.001 #

   Current

50% (21/42)

42% (35/84)

 

   Ex-smoker

14% (6/42)

4% (3/84)

 

   Never smoked

36% (15/42)

21% (18/84)

 

   Status not known

0

32% (27/84)

 

Hypertension

36% (15/42)

40% (34/84)

0.799

  1. Median and range are given for continuous variables, proportions for categorical variables. Mann–Whitney U-test was used for continous and Fisher’s Exact test for categorical variables. NA, Not applicable.
  2. * The percentage of unknown family histories is very high, especially in the PRIOR SAH group (76%, 64/84) making conclusions of the familial background unreliable.
  3. #Although the difference of smoking habits between patients with unruptured sIAs and a history of aneurysmal SAH was highly significant, it is important to notice that in the SAH group the smoking history of 32% of patients was not unknown, which may significantly affect the result.