Figure 4

Alpha synuclein associated pathology in the striatum. Lower and higher magnification images of axons in the striatum of animals expressing V1S SV2 or full length venusYFP (a). Beaded dystrophic axons are observed only in animals expressing α-syn compared to animals expressing venusYFP showing neurites with a normal appearance (a). VenusYFP fluorescence and α-syn immunostaining were both diminished following PK treatment suggestive to the soluble nature of visualized oligomers (b). Scale bar 200 μm upper panel a and 50 μm lower panel a and panel b.