Table 2 Pathological findings in the CNS of NMO and MS patients and controls
Case | CNS | Granulocyte | Complement | IL-1β | ||
|---|---|---|---|---|---|---|
number | diagnosis | CNS area | Lesion activity | infiltration | deposition | reactivity |
1 | NMO | spinal cord | initial/active | +++ | yes | +++ |
1 | NMO | spinal cord | initial/active | +++ | yes | +++ |
2 | NMO | medulla oblongata | initial/active | + (1 area) | yes | +++ |
3 | NMO | spinal cord | initial/active | +++ | yes | ++ |
1 | NMO | spinal cord | late/active | + | yes | + (astrocytes) |
4 | NMO | medulla oblongata | late/active | + | low | ++ |
3 | NMO | optic chiasm | late/active | +++ | low | ++ |
1 | NMO | pons | inactive | - | no | - |
1 | NMO | mesencephalon | inactive | - | no | - |
1 | NMO | frontal cortex + WM | inactive | - | no | - |
1 | NMO | frontal cortex + WM | inactive | - | no | - |
5 | acute MS | occipital cortex | initial/active | - | no | - |
6 | acute MS | cerebellum + WM | initial/active | - | no | - |
7 | acute MS | cortex + WM | initial/active | - | no | - |
8 | acute MS | parietal cortex + WM | initial/active | + | no | + |
9 | acute MS | parietal cortex + WM | initial/active | - | no | - |
10 | acute MS | medulla oblongata | initial/active | - | no | +/− (single cells) |
10 | acute MS | spinal cord | initial/active | - | no | +/− (single cells) |
11 | RRMS | spinal cord | initial/active | - | no | - |
12 | PMS | spinal cord | active | - | no | - |
13 | PMS | optic chiasm | late/active | - | no | - |
14 | PMS | spinal cord | late/active | - | no | - |
15 | PMS | spinal cord | late/active | - | no | +/− (microglia) |
16 | PPMS | insular cortex + WM | initial/active | - | no | - |
17 | SPMS | periventricular WM + basal ganglia | chronic | - | no | - |
18 | HSE | hippocampus | - | - | no | +++ |
19 | No CNS pathology | cortex + WM | - | - | no | - |
20 | No CNS pathology | temporal cortex + WM | - | - | no | - |