Figure 3
From: Epilepsy: neuroinflammation, neurodegeneration, and APOE genotype
Epilepsy-induced neuronal stress affects neuronal size in an APOE genotype-dependent fashion. Neurons in tissue from epilepsy patients were immunoreacted with a pan neuronal marker (green). The apparent large size of neurons in patients with APOE ϵ2,3 (A) and those in patients with APOE ϵ3,3 (B) relative to those in patients with APOE ϵ2,4 (C), APOE ϵ3,4 (D), and APOE ϵ4,4 genotype (E) was confirmed by measuring cross-sectional areas of neurons (μm2) in Groups 1,2,3,4, respectively (432 ± 40; 389 ± 29; 294 ± 20; vs 213 ± 17; p < 0.001) (F).