Figure 1

The relationship between neuronal expression of ApoE and glial expression of IL-1α, relative to APOE genotype. IL-1α (green)-immunoreactive microglia clustered around individual ApoE-immunoreactive neurons (red) in patients with APOE ϵ2,3 (A), APOE ϵ4,4 (B), APOE ϵ3,4 (C), and APOE ϵ3,3 (D). A maximum of 9 microglia per neuron were counted in APOE ϵ3,3 patients (arrow in D); this was higher than the numbers associated with other APOE genotypes as shown in the percentage of neurons with adjacent IL-1α immunoreactive neurons (none to nine) relative to APOE genotype (E).