Figure 3
From: Identification of a neuronal transcription factor network involved in medulloblastoma development
A neuronally enriched transcription factor network is defined by MB CIS genes. MB CIS genes (enlarged) linked via nearest neighbours are shown. The topological arrangement of connected CIS nodes is highly significant (p<0.006) as the average minimum path distance between the 7 CISs is lower than in 994/1000 randomly resampled networks. All network edges are supported with a bootstrapped p-value of <1x10-8. Genes identified as biallelically mutated MB CISs by Wu et al. [30] are shown as diamonds. Genes with transcription regulator activity (GO ID 30528) are shown in yellow. Genes with enriched ontologies associated with differentiated neurons (GO IDs 45202, 44456, 45211, 43005, 43198) are shown in green. Other genes with a known role in neuronal development are shown with a green border. For details of network construction, see Additional file 7. For details of enriched ontologies see Additional file 6: Table S4.