Fig. 1

Hierarchical clustering of transcriptomes of all patient-matched melanoma metastases. Each patient developed an intracranial metastasis (B, grey) and an extracranial metastasis in the course of its disease. Extracranial metastases appeared in either lung (Lun, blue), lymph node (Lym, green), skin (Ski, yellow), liver (Liv, pink), small intestine (Smi, light green) or soft tissue (Sof, purple). Multiple samples of the same metastasis were taken if the metastasis showed histologically different regions. Metastases of the same patient mostly co-cluster together. The few exceptions from this observation are marked with an asterisk ’*’. Affiliation with one of the three main clusters is marked in the lowest color bar (left cluster: pink, middle cluster: brown, right cluster: yellow). Stability of individual clusters is quantified by the red AU value, where 100 means that a cluster was perfectly stable