Figure 4

Pathological inclusions identified in similar sections of the same cases examined with pTDP43 and iTDP43. NCIs were observed in the cortex on sections with pTDP43 (A), but not in the same region of sections with iTDP43 (B) in Patient #8. Moderate NCIs were observed in the dentate gyrus on sections with pTDP43 (C) whereas only mild NCIs were observed in the same region on sections with iTDP43 (D, arrows) in Patient #10. Compared to the NCIs observed in the upper cortices in Patient #6 with pTDP43 (E, black arrows), iTDP43 sections demonstrated less NCIs (G, black arrows) and a loss of TDP43 nuclear staining in surrounding neurons (G, white arrows). In Patient #1, NCIs were identified in the dentate gyrus in a case examined with pTDP43 (F), but not in sections with iTDP43 (H) although this antibody demonstrated mild loss of nuclear staining in surrounding neurons (white arrows). NIIs were observed in the cortices of four cases (Patients #1, 3, 4, 5) with pTDP43 (I) but were identified only in one case (Patient #1) with iTDP43 (J). Scale in A ( equivalent for B,C,D,E,F,I and J), Scale in G (equivalent for H).